Research: Cameroon and South Africa
Infectious Disease: The major areas of research interest are in translational research directed to the development and implementation of inexpensive point of care assays for TB drug resistance or markers of HIV and TB disease pathogenesis. Several studies directed to the development of traditional therapies for TB and the study of biofilm in TB and Candida species are underway in collaboration with Dr. Charlene Africa in the department of Medical Biosciences at the University of Western Cape in Cape Town, South Africa. Dr. McArthur is using antimicrobial peptides to target biofilm formation.
Her lab in Cameroon was selected by the global alliance for TB drug development as a potential TB drug trial site and she has received multiple awards for capacitance-building in Africa. Faculty and students are able to participate in clinical rotations and specific research projects by arrangement with Dr. McArthur. You may contact her at firstname.lastname@example.org or 816-235-2175.
Cameroon Clinic University of Missouri Lab in Kansas City
Autoimmune Disease: Dr. McArthur is studying the mechanism by which autoantigens are processed and become immunogenic. This is carried out in salivary gland cells in vitro undergoing apoptosis induced by cytokines such as Tumor Necrosis Factor (TNF). This includes the cellular localization of these antigenic complexes, their redistribution, and structural modification following cell death.
Salivary gland in vitro models transfected with viral genes are employed to study the mechanism of exocrine gland destruction in AIDS and autoimmune diseases such as Lupus, Sjögren's Syndrome and Rheumatoid Arthritis. The HIV-1 tat gene is a powerful transactivator of gene expression. HIV-tat transfected salivary gland cells have been developed to understand the effect of tat on cytokines, onocogenes, MMPs and on gene expression of basement membrane proteins such as collagen and laminin involved in pathogenesis