Oral and Craniofacial Sciences Faculty






















Recent Publications (More articles at PubMed)

Tümpel, S., Cambronero, F., Wiedemann, L. and Krumlauf, R., (2006) Evolution of cis-elements in the differential expression of two Hoxa2 co-paralogous genes in pufferfish. PNAS 103: (In press).

Inoue, T., Correia, K. and Krumlauf, R. (2006) Electroporation of living embryos. IN Cell Biology, Elsevier Science (USA) 32-35.

Ferretti, E., Cambronero, F., Tuempel, S., Longobardi, E., Wiedemann, L.M., Blasi, F., and Krumlauf, R. (2005) The Hoxb1 enhancer and control of rhombomere 4 expression: Complex interplay of Prep1-Pbx1-Hoxb1 binding sites. Molecular and Cellular Biology 25:8541-8552.

Serpente, P., Tuempel, S., Ghyselinck, N., Niederreither, K., Wiedemann, L. Dollé, P., Chambon, P., Krumlauf, R. and Gould, A. (2005) Hindbrain expression of RARis induced by retinoic acid and then sequentially regulated by Hox genes. Development 132: 503-513.

Trainor, P., Bronner-Fraser, M. and Krumlauf, R. (2004) Neural crest cells: development and patterning of an embryonic stem cell population. In: Handbook of embryonic stem cells. Lanza et al (eds), Elsevier, San Diego Vol 1: 219-232.

Powles, N., Marshall, H., Economou, A., Chiang, C., Murakami, A., Dickson, C., Krumlauf, R., and Maconochie, M. (2004) Regulatory analysis of the mouse Fgf3 gene: Identification of an enhancer that mediates embryonic expression patterns and its partial dependence upon sonic hedgehog signalling. Developmental Dynamics 230:44-56.

Mercurio, S., Latinkic, B, Itasaki, N, Krumlauf, R and Smith, J.C. (2004) Connective-tissue growth factor (CTGF) modulates Wnt signalling and interacts with the Wnt receptor complex. Development, 131: 2137-2147.

Kusumi, K., Mimoto, M., Covello, K.l, Beddington, R., Krumlauf, R. and Dunwoodie, S. (2004) Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes. Genesis 39: 115-121.

Ivins, S., Pemberton, K., Krumlauf, R. and Zelent, A. (2003) Regulation of Hoxb2 by APL associated PLZF protein. Oncogene, 22: 3685-3697.

Pattyn, A., Vallstedt, A., Dias, J.C., Samad, O.A., Krumlauf, R., Rijli, F. M., Brunet, J. F., and Ericson, J. (2003) Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors. Genes and Development, 17: 729-737.

Itasaki, N., Jones, C.M., Mercurio, S., Rowe, A., Domingos, P.M., Smith, J.C. and Krumlauf, R. (2003) Wise, a context dependent activator or inhibitor of Wnt signalling. Development, 130: 4295-4305.

Gavalas, A, Rurhberg, C, Livet, J, Henderson, C and Krumlauf, R. (2003) Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes. Development, 130:5663-79.

Trainor, P., Sobieszczuk, D., Wilkinson, D., and Krumlauf, R. (2002) Signaling between the hindbrain and paraxial tissues dictates neural crest migration pathways. Development, 129, 433-442.

Manzanares, M., Nardelli, J., Gilardi-Hebenstreit, P., Marshall, H., Martinez-Pastor, M., Krumlauf, R. and Charnay, P. (2002) Krox20 and kreisler cooperate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain. EMBO J. 21, 365-376.

Theil, T., Ariza-McNaughton, L., Manzanares, M., Brodie, J., Krumlauf, R. and Wilkinson, D. G. (2002) Requirement for down-regulation of kreisler during late patterning of the hindbrain. Development , 129, 1477-1485.

Tümpel, S., Maconochie, M., Wiedemann, L. and Krumlauf, R. (2002) Conservation and diversity in the cis-regulatory networks that integrate information controlling express of Hoxa2 in hindbrain and cranial neural crest cells in vertebrates. Developmental Biology, 246, 45-55.

Trainor, P., Ariza-McNaughton, L and Krumlauf, R. (2002) Role of the isthmus and FGFs in resolving the paradox of neural crest plasticity and prepatterning. Science, 295, 1288-1291.

Trainor, P. and Krumlauf, R. (2002) Riding the crest of the Wnt signalling wave. Science, 297, 781-783.

Bel-Vialar, S., Itasaki, N. and Krumlauf, R. (2002) Initiating Hox gene expression in the chick neural tube: Differential sensitivity to FGF and RA signalling defines two distinct groups of Hoxb genes. Development 129, 5103-5115.

Krumlauf, R. (2002) Spring forward and fall back: Dynamics in formation of somite boundaries. Dev. Cell, 3, 605-606.

Trainor, P. and Krumlauf, R (2001) Hox genes, neural crest cells and branchial arch patterning. Current Opinion in Cell Biology, 13, 698-705.

Inoue, T. and Krumlauf, R. (2001) An impulse to the brain-in vivo electroporation. Nature Neuroscience Suppl. 4, 6-8.

Krull, C. and Krumlauf, R. (2001) Building from the bottom up. Nature Cell Biology 3, E138-139.

Kusumi, K., Dunwoodie, S. and Krumlauf, R. (2001) Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system. Mechanisms of Development, 100, 141-144.

Maconochie, M., Nonchev, S., Manzanares, M., Marshall, H. and Krumlauf, R. (2001) Differences in Krox20-Dependent Regulation of Hoxa2 and Hoxb2 during Hindbrain Development. Developmental Biology, 233, 468-481.

Kwan, C-T., Tsang, S-L, Krumlauf, R., and Sham, M-H. (2001) Regulatory analysis of the mouse Hoxb3 gene: Multiple elements work in concert to direct temporal and spatial patterns of expression. Developmental Biology, 232, 176-190.

Di Rocco, G., Gavalas, A., Pöpperl, H., Krumlauf, R., Mavilio, F. & Zappavigna, V. (2001) The recruitment of SOX/OCT complexes and the differential activity of HOXA1 and HOXB1 modulate the Hoxb1 auto-regulatory enhancer function. J. Biological Chemistry, 276, 20506-20515.

Gavalas, A., Trainor, P., Ariza-McNaughton, L., and Krumlauf, R. (2001) Synergy between Hoxa1 and Hoxb1: The relationship between arch patterning and the generation of cranial neural crest. Development, 128, 3017-3027.

Manzanares, M., Bel-Vialar, S., Ariza-McNaughton, L., Ferretti, E., Marshall, H., Maconochie, M., Blasi, F. and Krumlauf, R. (2001) Independent regulation of initiation and maintenance phases of Hoxa3 expression in the vertebrate hindbrain involve auto and cross-regulatory mechanisms. Development, 128, 3595-3607.

Domingos, P.M., Itasaki, N., Jones, C.M., Mercurio, S., Sargent, M.G., Smith, J.C. and Krumlauf, R. (2001) The Wnt/β-catenin pathway posteriorizes neural tissue in Xenopus by an indirect mechanism dependent upon FGF signalling. Developmental Biology. 239, 148-160.

Gavalas, A. and Krumlauf, R. (2000) Retinoid signalling and hindbrain patterning. Current Opinion in Genetics & Development 10, 380-386.

Trainor, P. and Krumlauf, R. (2000) Patterning the cranial neural crest: Hindbrain segmentation and Hox gene plasticity. Nature Reviews Neuroscience 1, 116-124.

Manzanares, M. and Krumlauf, R. (2000) Raising the roof. Nature 403, 720-721.

Ferretti, E., Marshall, H., Pöpperl, H., Maconochie, M., Krumlauf, R., and Blasi. F. (2000) Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins. Development, 127, 155-166.

Kmita, M., van der Hoeven, F., Zákány, J., Krumlauf. R. and Duboule, D. (2000) Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex. Genes and Development, 14, 198-211.

Trainor, P. and Krumlauf, R. (2000) Plasticity in mouse neural crest cells reveals a novel patterning role for cranial mesoderm. Nature Cell Biology, 2, 96-102.

Golding, J.P., Trainor, P., Krumlauf, R. and Gassmann, M. (2000). Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4. Nature Cell Biology, 2, 103-109.

Bulman, M.P., Kusumi, K., Frayling, T.M., McKeown, C., Garrett, C., Lander, E.S., Krumlauf, R., Hattersley, A.T., Ellard, S. & Turnpenny, P.D. (2000) Mutations in the human Delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. Nature Genetics 24, 438-441.

Manzanares, M., Trainor, P., Ariza-McNaughton, L., Nonchev, S. & Krumlauf, R. (2000) Dorsal patterning defects in the hindbrain, roof plate and skeleton in the drehe (drJ) mouse mutant. Mechanisms of Development, 94, 147-156.

Manzanares, M., Wada, H., Itasaki, N., Trainor, P. Krumlauf, R. and Holland, P.W.H. (2000) Conservation and elaboration of Hox gene regulation during evolution of the vertebrate head. Nature 408, 854-857.

Manzanares,M., Cordes,S., Ariza-McNaughton, L., Sadl, V., Maruthainar, K., Barsh, G. and Krumlauf, R. (1999). Conserved and distinct roles of kreisler in regulation of the paralogous Hoxa3 and Hoxb3 genes. Development, 126: 759-769.

Sharpe, J., Lettice, L., Hecksher-Sørensen, J., Fox, M., Hill, R. and Krumlauf, R. (1999). Identification of Sonic hedgehog as a candidate gene responsible for the polydactylous mouse mutant Sasquatch.. Current Biology, 9: 97-100.

Maconochie, M., Krishnamurthy, R., Nonchev, S., Meier, P., Manzanares, M., Mitchell, P.J. and Krumlauf, R. (1999) Regulation of Hoxa2 in cranial neural crest cells involves members of the AP-2 family. Development, 126: 1483-1494.
Davenne, M., Maconochie, M., Neun, R., Pattyn, A;, Chambon, P., Krumlauf, R. and Rijli, F.M. (1999). Hoxa2 and Hoxb2 Control Dorsoventral Patterns of Neuronal Development in the Rostral Hindbrain. Neuron, 22: 677-691.

Manzanares, M., Trainor, P., Nonchev, S., Ariza-McNaughton, L., Brodie, J., Gould, A., Marshall, H., Morrison, A., Kwan, C-T., Sham, M-H., Wilkinson, D.G. and Krumlauf, R. (1999) The Role of kreisler in Segmentation during Hindbrain Development. Developmental Biology, 211: 220-237.

Locascio, A., Aniello, F., Amoroso, A., Manzanares, M., Krumlauf, R. and Branno, M. (1999) Patterning the ascidian nervous system: structure, expression and transgenic analysis of the CiHox3 gene. Development, 126: 4737-4748.

Itasaki, N., Bel-Vialar, S. & Krumlauf, R. (1999) "Shocking" developments in chick embryology: electroporation and in ovo gene expression. Nature Cell Biol. 1:E203-207.

Robert Krumlauf, Ph.D.Research Associate Professor

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