Mineralized Tissue Biology

Mineralized Tissue Biology



















Contact Information:


The Bone Biology Research Program is composed of bone biologists with specific and unique skills that together compose a comprehensive team for the study of mineralized tissues. Dr. Mark Johnson is the discoverer of the high bone mass gene, Lrp5. Dr. Jeff Gorski and Dr. Sarah Dallas are experts in bone matrix, its components and functions. Dr. Yasuyoshi Ueki is a molecular biologist examining the condition of Cherubism. The technology available for the study of mineralized tissues include genomics, proteomics, transgenic mice, dynamic imaging, bone analysis for properties such as density, hardness, strength, and histomorphometry for analysis of both bone and bone cells. 3D microscopy, applications of mechanical strain, both in vitro and in vivo, are established among other technologies. The goal of the program is to approach important issues in bone and tooth development, physiology, and disease from basic experiments to clinical research. In vitro approaches are first necessary to properly design transgenic approaches which are essential before clinical trials. All three components, basic, translational and clinical research, are essential for translating findings into prevention of disease and treatment in the clinic. For details concerning the personal research studies of each faculty member, visit their websites or contact them by email.

Bone Biology Research Team:

Mark Johnson, Chair, Oral & Craniofacial Sciences, Professor. Research Focus: the role of the high bone mass gene Lrp5 in bone formation and regulation by mechanical strain. (johnsonmark@umkc.edu)
Sarah Dallas, Lefkowitz Professor, is the Director of the Dynamic Imaging Laboratory. Research Focus: the role of the latent transforming beta binding protein in bone extracellular matrix and in tumor metastasis to bone. (dallass@umkc.edu)

Jeff Gorski, Professor, is the Director of the Laser Capture Microdissection Microscopy Facility. Research Focus: extracellular matrix protein, specifically, BAG-75 and bone formation in the marrow ablation model. (gorskij@umkc.edu)

Yasuyoshi Ueki, Assistant Professor, is engaged in research in the areas of molecular and cellular pathogenesis of the human craniofacial disorder, Cherubism. (uekiy@umkc.edu)

The Bone Biology Program collaborates and integrates research goals with the Biomaterials and Engineering Components of the Department of Oral and Craniofacial Sciences. These investigators include Dr. David Eick, Curator’s Professor Emeritus, and Dr. Yong Wang, Professor, experts in Biomaterials and their analyses. For more information concerning research in these areas click Biomaterials/Bioengineering Program.

The Bone Biology Program investigators collaborate and integrate research goals with Dr. Lynda F. Bonewald, Distinguished Curator’s Professor Emeritus, the Executive Director of Indiana Center for Musculoskeletal Health, Professor of Anatomy & Cell Biology and Orthopaedic Surgery, School of Medicine, Indiana University. Research Focus: on the effects of mechanical strain on osteocyte biology. 5-Lipoxygenase, Transforming Growth Factor beta. (bonewaldl@umkc.edu -  lbonewal@iu.edu)

For training opportunities in the Bone Biology Program contact Dr. Mark Johnson or see Educational Opportunities on the homepage. For information on the Oral and Craniofacial Sciences Seminar Series click here.