Oral and Craniofacial Sciences Faculty

H. Clarke Anderson





















Dr. H. Clarke Anderson is Prof. Emeritus of Pathology and Harrington Prof. of Orthopedic Research at the University of Kansas Medical Center (e-mail address: handerso@kumc.edu). Dr. Anderson received his M.D. degree from the University of Louisville School of Medicine (1958). He served his internship and residency in anatomic Pathology at the Massachusetts General Hospital (Boston) and Memorial Sloan Kettering Cancer Center (New York). He was a Post-Doctoral Research Fellow at the Sloan Kettering Institute for Cancer Research (1962-1963). From 1963 to 1978 he served on the Pathology faculty at the State University of New York, Downstate Medical Ctr., and held the ranks of Asst. Prof. to Prof. of Pathology. He was Professor and Chair of the Dept. of Pathology, K.U. Med. Ctr., 1978-1990, and now occupies the position of Prof. Emeritus at KUMC. He was visiting Research Fellow at Strangeways Lab and Cambridge University, Cambridge, England (1971-1972) and in the Dept. of Cell Biology, Yale University School of Medicine (1985-1986). His research focuses on the cell biology and ultrastructure of: 1) the mechanism of induction of new bone and bone marrow in muscle and subcutaneous tissues, by cultured human cells and extracts thereof. In this area, he was the discoverer of an as yet incompletely defined bone inducing-agent, first in FL cultured human amniotic (placental) cells, and more recently in the Saos-2 cell line of human osteosarcoma cells. 2) In 1967-1969 he discovered matrix vesicles, i.e. submicroscopic (100 nanometer) vesicles, released by the cells of bone, growth plate cartilage and teeth (dentin), that serve as the initial site of normal biomineralization as well in pathological calcification of arteries, tumors, kidneys and at other sites in the body. His research continues to be focused on bone induction, bone repair, and the role of matrix vesicles in biomineralization.

H. Clarke AndersonAdjunct Faculty

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