MusculoSkeletal Structure/Property Characterization Core

Charlotte L. Phillips, Ph.D.





















Dr. Charlotte L. Phillips, Associate Professor of Biochemistry, University of Missouri. Her research interests include the investigation of the regulation and structure/function of extracellular matrix to tissue specific expression in the pathogenesis of inherited connective tissue disorders. Type I collagen, the predominant structural protein in many tissues provides strength to bone and tendon, integrity to skin, major organs and blood vessels, and support for mineralization of bone and teeth. Abnormalities in type I collagen synthesis and structure are associated with several acquired and inherited connective tissue disorders (osteogenesis imperfecta, Ehlers-Danlos Syndrome and osteoporosis). Investigating the pathogenesis of the different inherited connective tissues disorders and identifying the specific mutations in the type I collagen genes gives us insight into the multi-structural/functional roles of type I collagen in different tissue

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Charlotte L. Phillips, Ph.D.

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